Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma
نویسندگان
چکیده
منابع مشابه
Metabolic Reprogramming in Mutant IDH1 Glioma Cells
BACKGROUND Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 catalyzes the conversion of α-ketoglutarate into 2-hydroxyglutarate. These mutations are associated with the accumulation of 2-hydroxyglutarate ...
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A1 Investigations of the functional interactions between CIC and ATXN1L in Oligodendroglioma D. Wong, V. Leblanc, S. Chittaranjan, M. Marra, S. Yip BC Cancer Agency, UBC, Vancouver, BC, Canada doi:10.1017/cjn.2017.2 Oligodendroglioma (ODG) is a subtype of low grade glioma marked by unique clinical and genomic characteristics including slow predictable progression, IDH mutation, and 1p19qcodelet...
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OBJECTIVE The purpose of this study was to perform a survival analysis of patients with high-grade multicentric gliomas and to assess the influence of various prognostic factors on overall survival (OS). METHODS A literature search on PubMed and Web of Science was performed for literature in English published from 1880 to October 2017. Detailed information including demographics, clinical cha...
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CMYK371 tradural extension was seen in two patients. On MRI about 75% of ganglioneuromas are isointense and 25% are hypointense on T1 images. Most of them are hyperintense on T2 images. The non-homogeneous appearance corresponds to areas of cystic degeneration, hemorrhage or necrotic degeneration. Ganglioneuromas are well encapsulated tumors and can be completely excised. Even when they are int...
متن کاملIDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway
PURPOSE Numerous studies have reported that glioma patients with isocitrate dehydrogenase 1(IDH1) R132H mutation are sensitive to temozolomide treatment. However, the mechanism of IDH1 mutations on the chemosensitivity of glioma remains unclear. In this study, we investigated the role and the potential mechanism of Nrf2 in IDH1 R132H-mediated drug resistance. METHODS Wild type IDH1 (R132H-WT)...
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ژورنال
عنوان ژورنال: Pathobiology
سال: 2016
ISSN: 1015-2008,1423-0291
DOI: 10.1159/000447951